The same level of lightweight aluminum hydroxide in buffered saline without antigen was utilized as a placebo. Both vaccine and placebo were prepared in a facility that was compliant with Great Manufacturing Procedures and were tested by the National Institutes for Meals and Drug Control prior to the start of the study. Study Design and Participants This randomized, double-blind, placebo-controlled clinical study was designed by the Institute of Medical Biology, the guts for Drug Evaluation in the constant state Food and Medication Administration, and the guts for Disease Control and Prevention of the Guangxi Zhuang Autonomous Area .Second, there are no options for monitoring sufferers who are treated with natalizumab for the first recognition of PML. Clinical vigilance for symptoms suggestive of PML, which to some extent overlap with those of multiple sclerosis, is necessary. Liberal usage of MRI is preferred for detection of changes that are usual of PML, but the differentiation of PML lesions from those related to multiple sclerosis can be challenging, as illustrated by the results in our patient, who had only a single lesion on MRI primarily, as opposed to the normal multifocal demonstration of PML.