Madinger, M.D., Charlene McEvoy, M.D., M.P.H., Dennis E. Niewoehner, M.D., Janos Porsasz, M.D., Ph.D., Connie S. Price, M.D., John Reilly, M.D., Paul D. Scanlon, M.D., Frank C. Sciurba, M.D., Steven M. Scharf, M.D., Ph.D., George R. Washko, M.D., Prescott G. Woodruff, M.D., M.P.H., and Nicholas R. Anthonisen, M.D. For the COPD Clinical Study Network: Azithromycin for Prevention of Exacerbations of COPD Acute exacerbations of chronic obstructive pulmonary disease result in regular visits to physicians’ offices and emergency rooms and numerous hospitalizations and days lost from work; they also account for a considerable %age of the cost of treating COPD.1-5 Patients who’ve acute exacerbations of COPD, as compared with patients with COPD who don’t have acute exacerbations, have an elevated risk of loss of life, a far more rapid decline in lung function, and reduced standard of living.6-11 Although inhaled glucocorticoids, long-acting beta2-agonists, and long-acting muscarinic antagonists reduce the frequency of severe exacerbations of COPD,12-24 patients receiving all three of these medications may still have as much as 1.4 acute exacerbations, normally, each year.23 Macrolide antibiotics possess immunomodulatory, antiinflammatory, and antibacterial results.Hess, M.D., Cindy Leissinger, M.D., and Suzanne Granger, M.S.: Dosage of Prophylactic Platelet Avoidance and Transfusions of Hemorrhage The optimal number of platelets in a prophylactic platelet transfusion is usually controversial. 3 Higher doses than these you could end up superior hemostasis potentially, 4 but a lesser dose might be effective while conserving the platelet supply equally. In both trials, the two dosages prevented bleeding to an identical degree. We conducted a randomized trial of prophylactic platelet transfusions to look for the effects of the dosage of platelets on scientific signs of bleeding, the use of red-cell and platelet transfusions, adjustments in the recipient’s post-transfusion platelet count, days to following transfusion, and adverse occasions.7 Methods A subcommittee of the Transfusion Medication/Hemostasis Clinical Trials Network investigators designed the scholarly study and wrote the manuscript, that was reviewed by all authors.