We remain on track to submit an NDA for the NanoTab System later this year. They state that repeated non-physiological surges in synaptic dopamine during severe [levodopa] dosing could potentially lead to persistent dysfunction of important enzymes of the intracellular signalling cascade that are involved in the induction and maintenance of both forms of plasticity. Motor problems are known to develop in response to levodopa therapy as PD progresses. Asha Kishore and co-investigators show that electric motor complications are associated with a loss in both long – and short-duration response of electric motor cortex plasticity to levodopa. Related StoriesNew analysis finds insufficient evidence for usage of Omega 3 products in treating main depressive disorderResearchers recognize potential brain-based biomarker for depressive symptomsNegative body picture significantly increases obesity risk among adolescents If the impairment in plastic material response of engine cortex is a trigger or a consequence of the motor complications remains an open question, they write in Mind.Topical Psoriasis treatment If the certain region suffering from psoriasis is little, then it could possibly be treated with topical remedy. Topical therapy refers to the use of creams, sprays or lotions on the affected region. A lot of the topical medicines are readily available more than the counter and some are offered only for prescription. The majority of the topical drugs contain corticosteroids because of their anti-inflammatory properties. They may also include coal tar and salicylic acid approved by FDA.