For patients in the delayed-intervention group, revascularization could occur at any time after coronary angiography. Blood was drawn for evaluation of the creatine kinase MB fraction and troponin level before revascularization and at 6 to 8 8 hours and at 12 to 14 hours after revascularization. Electrocardiography was performed 12 to 18 hours after revascularization. The selection of the mode of revascularization was predicated on patients’ characteristics and preferences, the extent of disease, the absence or presence of coexisting illnesses, and the known level of left ventricular function. Protocol requirements for crossover from the delayed-intervention group to the early-intervention group and recommended pharmacologic therapies are defined in the Supplementary Appendix.Gastrointestinal events occurred frequently, but the frequency didn’t differ significantly between your groups. Attenuation of the acute inflammatory response was hypothesized to end up being part of the beneficial aftereffect of early feeding. However, such an effect didn’t take place . In a predefined subgroup analysis restricted to sufferers with an APACHE II score of 13 or more at randomization, the occurrence of the primary end point did not differ significantly between the two treatment groups . Post hoc subgroup analyses also did not show a significant between-group difference in the primary end point for patients with SIRS at randomization or those with a BMI of less than 25 or 35 or even more .