Total serum ALP ought to be measured in a patient who offers symptoms of cholestatic liver disease, bone pain, low bone mineral density , or general debility. An isolated elevated serum ALP level is usually due to increased osteoblast activity. ALP is elevated in several bone conditions. If an increased total ALP is normally accompanied by an elevated gamma glutamyl transpeptidase level then the cause is most likely of liver origin.. Alkaline phosphatase: when to measure it all and what to do next Alkaline phosphatase measurement is among the hottest and simple biochemical assessments, and an useful marker of bone and liver disease extremely.The investigators utilized diagnostic codes to track sufferers treated for Lyme disease. The data showed that almost 107 cases of Lyme disease occur annually for each and every 100,000 people in the usa. Based on that, experts estimated that about 329,000 new cases crop up every year. September issue of the CDC journal Emerging Infectious Diseases The record is published in the. Lyme disease is concentrated heavily in the Northeast and upper Midwest, with 80 % of all doctor-diagnosed instances occurring in 14 says and the District of Columbia, the study authors said. The very best Lyme disease states – – in rank order of average cases – – are Connecticut, Rhode Island, Maryland, NJ, Massachusetts, NY, New Hampshire, Pennsylvania, Maine, Delaware, Virginia, Vermont, Minnesota and Wisconsin.