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Nearly all adverse events reported by investigators had been mild to moderate, with the most common getting nausea, diarrhea, vomiting, qT and anemia prolongation. Nearly all serious adverse events were disease related. A maximum tolerated dosage has not been reached. Efficacy Data Agios also analyzed efficacy data from 55 response-evaluable individuals as of September 3, 2015, which showed: Treatment with AG-120 showed substantial reduced amount of the oncometabolite 2-hydroxglutarate in plasma and tumor tissue. Imaging results claim that AG-120 can lower 2HG in the brain. Chondrosarcoma: Seven of the 11 patients with IDH1 mutant positive chondrosarcoma experienced stable disease.After the age of 1 12 months, boys are more suffering from exposure to atmospheric lead than women. Furthermore, the gender difference increases with age, in a way that boys have a 1.5 percent higher blood lead level than girls surviving in the same area at age 1 year, and this increases to an 11.2 percent difference at age 7 years. ‘Taken together, these facts are suggestive of a [soil to air dirt to kid] pathway of contemporary business lead exposure, where lead-contaminated urban soils are resuspended as dust subject to seasonal precipitation regimes, wind, humidity, and various other meteorological factors, with surroundings lead dirt ingested and inhaled by unsuspecting children,’ conclude the authors.